Universidad Adventista del Plata in Argentina and completed her anatomic and clinical pathology residency and cytopathology fellowship at Thomas Jefferson University in Philadelphia , PA .
Saadia Haleema . Waqas Mahmud . Yanina Nikolaus .
Haleema , Mahmud and Nikolaus all serve as assistant professors at the Joan C . Edwards School of Medicine . Marshall Health pathologists work collaboratively with other clinicians throughout Marshall Health Network and area hospitals to evaluate blood / body fluid samples and microscopic tissues . Marshall Pathology also accepts specimens and cases from other health care facilities and physicians ’ offices for diagnosis or consultation .
WVU Rockefeller Neuroscience Institute Achieves Greater Reduction in Brain Amyloid Plaques
A potential advancement in the treatment of Alzheimer ’ s disease was announced recently by researchers at the West Virginia University Rockefeller Neuroscience Institute
( RNI ). A first in-human study , featured in the latest issue of the New England Journal of Medicine , demonstrates that focused ultrasound in combination with anti-amyloid-beta ( A ) monoclonal antibody treatment can accelerate the clearance of amyloid-beta plaques in the brains of patients with Alzheimer ’ s disease .
Monoclonal antibody therapies , such as aducaumab , lecanemab and donanemab , can reduce amyloid-beta plaques and slow the progression of Alzheimer ’ s . Until now , these promising antibody therapies had limitations in reaching the brain due to the blood-brain barrier ( BBB ), a protective barrier between blood vessels and the brain that blocks harmful substances from getting into the brain but also limits the access of therapeutics . More than 98 % of drugs do not readily cross the BBB , thus requiring systemic treatments with higher doses and more frequent therapies .
RNI scientists used a focused ultrasound system ( FUS ) developed by Insightec to safely and temporarily open the BBB to allow the A antibodies increased access to targeted areas of the brain . The FUS MRI-guided treatment helmet holds more than 1,000 ultrasound transducers , which were directed to specific brain regions with high amyloid-beta plaques .
In this first in-human proof-of-concept study , three patients — two male and one female , aged 59-77 — with mild Alzheimer ’ s disease received six standard monthly infusions of aducanumab antibody , immediately followed by FUS-mediated BBB opening in regions with high amyloidbeta plaques . The results demonstrated the safety of this
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